The archive of Centro de Estudios is extremely varied. The main characteristic is to maintain Mexican manuscripts. However, the collection includes some universal documents of major interest. One of these documents is signed by Queen Isabel la Catolica, dated in Valladoid in 1491, and the Appointment of Christopher Columbus in 1493, unique in its type in America.

The documental collection of the archive is divided in items identified by Roman numerals. Each groups different possibilities that may contain manuscripts, printed documents, copies or portraits and microfilms. Items cover a chronological order and range from 1491 to 1999, inclusively. These include the vice regal ages, the Independence war, the history of the 19th century, the Second Empire, a major part of the government of Porfirio Diaz, the Mexican Revolution and the 20th Century. Archives of private sources, artists or writers.

Cover of the general and natural history of the Indies (La Historia General de las Indias) by Gonzalo Fernandez de Oviedo. First edition, 1535.

Cover of the History of New Spain (Historia de la Nueva España) by Antonio de Solis (Madrid, 1864), which narrates the conquest of Mexico.

Items which are of different types, are grouped in the Different Acquisitions and specific collections of leading celebrities, such as Lucas Alaman, Enrique C. Creel, Porfirio Parra, Francisco Leon de la Barra, Venustiano Carranza, Pablo Gonzalez, Manuel W. Gonzalez, Felix Diaz, Federico Gonzalez Garza, Luis Montes de Oca, Antonio Carrillo Flores and Luis Chavez Orozco, Luis Gutierrez and Juan Sanchez Azcona.

In addition to documental items of the archive, the Center also maintains a photo library that includes different collections, such as the Hancock and Venustiano Carranza collections of Jose Mendoza; the collections of Federico Gonzalez Garza, Pablo Gonzalez, the Cristero   Movement collection, Antonio Rius Facius.